|
KMID : 1100720180380010001
|
|
Annals of Laboratory Medicine
2018 Volume.38 No. 1 p.1 ~ p.8
|
|
|
Cell-Free DNA in Oncology: Gearing up for Clinic
|
|
Ulrich Bryan C.
Paweletz Cloud P.
|
|
|
Abstract
|
|
|
|
In the past several years, interest in the clinical utility of cell-free DNA as a noninvasive cancer biomarker has grown rapidly. Success in the development of plasma genotyping assays and other liquid biopsy assays has widened the scope of cell-free DNA use in research and the clinic. Already approved by the US Food and Drug Administration in the narrow context of epidermal growth factor receptor-mutated non-small cell lung cancer, plasma genotyping assays are currently being investigated in a wide array of clinical settings and modalities. These include plasma genotyping as a tool for early diagnosis, the detection of minimal residual disease, and the evaluation of treatment response/progression. In this review, we assess the clinical landscape of plasma genotyping assays and propose strategies for their further expansion into routine clinical care.
|
|
|
KEYWORD
|
|
|
Liquid biopsy, Cell-free DNA, Plasma genotyping, Non-invasive biomarkers, Clinical trials
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
   
|